Parameter | Day 1 | Day 2 | ||||
---|---|---|---|---|---|---|
Mean ± S.D. | Median | Range | Mean ± S.D. | Median | Range | |
Cmax (μg/mL) | 74.9 ± 17.0 | 77.4 | 51.8 – 116.5 | 77.5 ± 12.9 | 75.8 | 61.6 – 106.0 |
Cmin (μg/mL) | 3.9 ± 2.5 | 3.7 | 0.2 – 9.1 | 6.2 ± 3.7 | 5.4 | 1.6 – 16.1 |
Vd (L/kg) | 0.20 ± 0.05 | 0.19 | 0.12 – 0.29 | 0.20 ± 0.04 | 0.20 | 0.14 – 0.27 |
Kel (h–1) | 0.15 ± 0.04 | 0.14 | 0.10 – 0.29 | 0.14 ± 0.03 | 0.14 | 0.07 – 0.20 |
CL (mL/h/kg) | 30.9 ± 14.5 | 24.5 | 14.2 – 72.6 | 29.0 ± 8.5 | 27.4 | 11.3 – 45.5 |
AUC0-24 h or AUC24–44 h (μg・h/mL) | 634 ± 154 | 611 | 423 – 1021 | 612 ± 126 | 586 | 424 – 852 |
AUC0-92 h (μg・h/mL) | 1332 ± 315 | 1282 | 870 – 2015 |  |  |  |