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Fig. 3 | Journal of Pharmaceutical Health Care and Sciences

Fig. 3

From: Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

Fig. 3

Plasma concentrations of tramadol, O-desmethylate, N-desmethylate, and N,O-didesmethylate obtained from patients with cancer pain (a) or non-cancer pain (b) just before treatment of oral tramadol on day 4 or later. (1) Tramadol, (2) O-desmethylate, (3) N-desmethylate, and (4) N,O-didesmethylate

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