Fig. 6
Comparisons of fluconazole doses for neonates and infants estimated using various formulas for children at PMA ranging from 28 to 60 weeks. Open (○) and closed circles (●) connected with solid lines represent doses predicted by fluconazole clearance normalized to body weight (CLBW) and fluconazole clearance normalized to body surface area (CLBSA), respectively in the present study. Open (□) and closed squares (■) represent those predicted by the Crawford’s and Augsberger’s formulas, respectively. The shaded area represents doses calculated according to the recommended doses for treating systemic candidiasis for children (3 to 6 mg/kg/day) in the latest prescribing information [3]