Table 5 Factors determining the occurrence of DRPs among neonates with sepsis
Variables | Drug-related problem identified | COR[95%CI] | p-value | AOR[95%CI] | p-value | ||
|---|---|---|---|---|---|---|---|
Yes (n = 98) | No (n = 103) | ||||||
Age of the neonate in days (M ± SD) | 14.6 ± 17.2 | 11.0 ± 15.3 | 0.9 [0.9–1.0] | 0.12 | 1.0 [0.9–1.0] | 0.80 | |
Birth weight (kg) (M ± SD) | 2.6 ± 0.7 | 2.8 ± 0.6 | 1.3 [0.8–2.0] | 0.19 | 0.7 [0.4–1.2] | 0.29 | |
On admission vomiting | Yes | 30 (30.6) | 16 (15.5) | 0.4 [0.2–0.8] | 0.01 | 2.2 [0.98–4.9] | 0.05 |
No | 68 (69.4) | 87 (84.5) | 1 | 1 | |||
Hemoglobin (M ± SD) | 13.7 ± 3.9 | 14.6 ± 3.5 | 1.0 [0.9–1.1] | 0.09 | |||
Oxygen saturation on admission (%) | 79.1 ± 10.8 | 81.7 ± 11.7 | 1.0 [0.9–1.0] | 0.11 | 0.9 [0.9–1.0] | 0.25 | |
Type of sepsis | EONS | 55 (56.1%) | 67 (65.0%) | 1.4 [0.8–2.5] | 0.19 | 0.8 [0.3–2.3] | 0.79 |
LONS | 43 (43.9%) | 36 (35.0%) | 1 | 1 | |||
Neonates taking antibiotics plus other medications | Yes | 53 (54.1%) | 40 (38.8%) | 0.5 [0.3–0.9] | 0.03 | 5.2 [1.2–22.0] | 0.02 |
No | 45 (45.9%) | 63 (61.2%) | 1 | 1 | |||
Number of medications taking during hospital stay (M ± SD) | 2.6 ± 0.6 | 2.5 ± 0.7 | 0.7 [0.5–1.1] | 0.21 | 0.4 [0.1–1.2] | 0.11 | |
Discharge status | Alive/discharged | 71 (72.4) | 85 (82.5) | 1.7 [0.9–3.5] | 0.08 | 0.5 [0.2–1.0] | 0.06 |
Death | 27 (27.6) | 18 (17.5) | 1 | 1 | |||