Fig. 2

Application to the validated method for quantification of authentic clinical samples. A Chromatograms of lacosamide in the patient samples were obtained 60 min after administration: (a) breast milk, (b) plasma, and (c) plasma ultrafiltrates. B Graph indicating lacosamide concentration in breast milk (●), plasma (▲), and plasma ultrafiltrate (△; free form of lacosamide). The patient was orally administered lacosamide twice daily (100 mg × 2). Plasma samples were obtained before and 60 min after oral administration of lacosamide. Breast milk samples were collected before and after administration (60, 115, 300, and 500 min).