Table 1 Intra- and inter-day reproducibility of lacosamide in human breast milk and plasma
Intra-day (n = 6) | Inter-day (n = 6) | ||||||
|---|---|---|---|---|---|---|---|
Spiked (ng/mL) | Found (ng/mL) | R.S.D.a (%) | R.E.b (%) | Found (ng/mL) | R.S.D.a (%) | R.E.b (%) | |
Breast milk | 0.5 | 0.432 | 0.8 | -13.7 | 0.442 | 13.4 | -11.7 |
1.25 | 1.32 | 8.0 | 5.5 | 1.30 | 6.8 | 4.0 | |
12.5 | 13.3 | 2.7 | 6.5 | 13.6 | 7.6 | 8.4 | |
80 | 78.6 | 3.7 | -1.7 | 82.4 | 6.5 | 2.9 | |
Plasma | 0.5 | 0.449 | 10.6 | -10.2 | 0.468 | 10.2 | -6.5 |
1.25 | 1.29 | 4.6 | 3.3 | 1.30 | 6.3 | 4.1 | |
12.5 | 14.1 | 4.3 | 13.1 | 13.0 | 7.5 | 4.0 | |
80 | 83.9 | 4.2 | 4.9 | 75.9 | 8.7 | -5.1 | |