Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk

Table 3 Dilution integrity

	Sample concentration (μg/mL)	Dilution factor	Nominal concentration (ng/mL)	Found concentration (ng/mL)	R.S.D.^a (%)	R.E.^b (%)
Breast milk	1	100	10	11.13	2.2	11.3
Breast milk	10	200	50	57.0	4.1	13.9
Plasma	1	100	10	11.05	2.7	10.5
Plasma	10	200	50	52.8	6.4	5.6

ISSN: 2055-0294