Fig. 3

HPLC chromatograms of SS (left) and EZ (right) suspended with or without MG under the SSM condition. The suspensions of the following formulations were prepared and treated by method I (A, B, C, E, F, G) or method II (D, H) and the resulting solutions were analyzed by HPLC. Unless otherwise noted, the analyses were performed immediately after disintegration for 10 min. The insets in panels B and F show the chromatograms of the aqueous supernatants of the co-suspensions with MG. The mobile phases and detection wavelengths; see Table 1. A SS; B and D SS + MG; C SS + MG (5 h later); E EZ; F and H EZ + MG; G EZ + MG (5 h later). symbols: 1, simvastatin; 2, ezetimibe; *, degradation product