Table 4 Degradation studies of cholesterol-lowering drugs under alkaline conditions
Drug | Condition | Degradation rate (%) | Literature |
|---|---|---|---|
Atorvastatin | 1 M NaOH, 60°C, 10 min | 4 | Khedr et al. [19] |
Pravastatin | 1 M NaOH, 80°C, 1 h | 89 | Önal et al. [21] |
Rosuvastatin | 0.01 M NaOH, 85°C, 10 h | 0 | Machairas et al. [22] |
Simvastatin | 28 mM phosphate buffer (pH 8), 60°C , 1.5 h | ca. 80a | Álvarez-Lueje et al. [24] |
Ezetimibe | 0.01 M, NaOH, 25°C, 5 min | 24 | Goel et al. [26] |