Fig. 1

Clinical laboratory results and measured plasma concentrations of tedizolid (solid circles) in two patients administered 200 mg once daily via intravenous infusion. Levels are shown of C-reactive protein (circles, mg/dL) and white blood cell counts (squares, µL^− 1) in the two patients: (A) a 79-year-old woman (48 kg), case 1, and (B) a 73-year-old woman (80 kg), case 2. The measured plasma concentrations of tedizolid (solid circles) in cases 1 (C) and 2 (D) are shown after once-daily administrations. Plasma concentrations of tedizolid (dashed lines) after virtual daily doses were generated using a previously reported one-compartment model [11], using Microsoft Excel