Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Table 1 Plasma and synovial fluid concentrations of tedizolid determined in two patients during surgery

Case (body weight)		Sampling	Tedizolid concentration (µg/mL)		Ratio of synovial fluid/plasma
Case (body weight)		Sampling	Plasma	Synovial fluid	Ratio of synovial fluid/plasma
1	79-year-old woman (48 kg)	Day 7	1.6 ± 0.1	2.1 ± 0.1	130%
2	73-year-old woman (80 kg )	Day 2	3.3 ± 0.2	2.9 ± 0.4	88%

Data are presented as the mean ± standard deviation from triplicate determinations
The tedizolid levels in the plasma and synovial fluid samples from the two patients at 5 and 7 h after the last administration on Days 7 and 2, respectively (Fig. 1), were quantified using liquid chromatography (Fig. 2)

ISSN: 2055-0294