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Table 1 Demographic and clinical characteristics of patients

From: Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation

Patient

No

Age

[years]

Sex

BW

[kg]

Primary

disease

Conditioning pretreatment

Type of

HSCT

RBC

[× 104/μL]

Hct

[%]

Hb

[g/dL]

Alb

[g/dL]

AST

[U/L]

ALT

[U/L]

T-bil

[mg/dL]

Cre

[mg/dL]

#1

4.3

M

13.3

CGD

ATG, BU, Flu, TBI

rPBSCT

332

28.9

9.9

3.8

43

121

0.3

0.18

#2

6.8

F

22.0

BCP-ALL

Mel, TBI

CBT

297

26.7

9.1

3.5

51

56

0.5

0.29

#3

9.6

F

35.2

AML

CY, TBI

CBT

290

26.2

8.9

3.3

76

89

0.8

0.24

#4

7.8

M

18.2

AML

BU, Mel

rPBSCT

312

32.5

10.7

2.6

113

150

0.5

0.23

#5

6.8

M

29.8

MDS

ATG, Flu, Mel, TBI

uBMT

348

33.1

11.5

3.6

51

109

1.2

0.32

#6

11.4

F

25.3

T-ALL

CY, VP-16, TBI

uBMT

287

28.2

9.6

2.4

96

95

3.5

0.24

#7

2.3

F

11.3

AML

BU, CY

CBT

315

33.2

10.9

3.2

27

47

0.4

0.13

#8

4.6

M

16.0

BCP-ALL

CY, VP-16, TBI

CBT

297

27.4

9.0

4.4

26

34

1.0

0.20

#9

2.6

F

9.8

EBV-LPD

Ara-C, Flu, Mel, MIT, VP-16, PSL

CBT

334

28.5

10.1

3.5

18

13

3.3

0.21

#10

0.7

F

7.3

CAMT

ATG, Flu, Mel

CBT

417

34.3

12.3

3.8

67

60

0.6

0.25

Median

(range)

5.7

(0.7–11.4)

 

17.1

(7.3–35.2)

   

314

(287–417)

28.7

(26.2–34.3)

10.0

(8.9–12.3)

3.5

(2.4–4.4)

51

(18–113)

75

(13–150)

0.7

(0.3–3.5)

0.23

(0.13–0.32)

  1. M Male, F Female, BW Body weight, CGD Chronic granulomatous disease, BCP-ALL B-cell precursor acute lymphoblastic leukemia, AML Acute myeloid leukemia, MDS Myelodysplastic syndromes, T-ALL T-cell acute lymphoblastic leukemia, EBV-LPD Epstein-Barr virus-associated lymphoproliferative disease, CAMT Congenital amegakaryocytic thrombocytopenia, HSCT Hematopoietic stem cell transplantation, ATG Anti-thymocyte globulin, BU Busulfan, Flu Fludarabine, TBI Total body irradiation, Mel Melphalan, CY Cyclophosphamide, VP-16 Etoposide, Ara-C Cytarabine, MIT Mitoxantrone, PSL Prednisolone, rPBSCT Related peripheral blood stem cell transplantation, CBT Cord blood transplantation, uBMT Unrelated bone marrow transplantation, RBC Red blood cell, Hct Hematocrit, Hb Hemoglobin, Alb Albumin, AST Aspartate aminotransferase, ALT Alanine transferase, T-bil Total bilirubin, Cre Serum creatinine