Fig. 4
From: Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
Effect of the TEP on IMC-Induced Gastric Ulcerogenic Lesions in AA Rats 14 day after Adjuvant Injection. A images of the stomach of IMC-treated AA rats treated with TEP. B–D effect of TEP on lesion area, NOS2 mRNA and NO levels in the stomach of IMC-treated AA rats. E and F image of H&E-stained E and OPN immunostained stomach tissue of IMC-treated AA rats treated with TEP. Both arrows, areas of desquamation. Open arrowheads, OPN immunostained-positive cells in the mucosal layer. Closed arrowheads, OPN immunostained-positive cells in the submucosal and muscular layers. Bars in the image indicate 50 µm. n=3–9. *P<0.05 vs control for each category. TEP attenuated the excessive NO via NOS2 levels, and promote recovery from IMC-induced gastric ulcerogenic lesions in AA rats