Fig. 5
From: Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
Effect of the TEP on IMC-Induced Jejunal Ulcerogenic Lesions in AA Rats 14 day after Adjuvant Injection. A images of the of IMC-treated AA rats treated with TEP. B–D effect of TEP on lesion area, NOS2 mRNA and NO levels in the jejunum of IMC-treated AA rats. E and F image of H&E-stained (E) and OPN immunostained jejunum tissue of IMC-treated AA rats treated with TEP. Squares, the tips of the intestinal villi in the mucosa of without TEP. Open arrowheads, OPN immunostained-positive cells in the mucosa. Closed arrowheads, OPN immunostained-positive cells in the mucosal myotome. Bars in the image indicate 50 µm. n=3–9. *P<0.05 vs control for each category. TEP attenuated the excessive NO via NOS2 levels, and promote recovery from IMC-induced jejunal ulcerogenic lesions in AA rats