Fig. 6
From: Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
Effect of the TEP on IMC-Induced Ileal Ulcerogenic Lesions in AA Rats 14 day after Adjuvant Injection. A images of the ileum of IMC-treated AA rats treated with TEP. B–D:effect of TEP on lesion area, NOS2 mRNA and NO levels in the ileum of IMC-treated AA rats. E and F image of H&E-stained (E) and OPN immunostained ileum tissue of IMC-treated AA rats treated with TEP. Squares, the tips of the intestinal villi in the mucosa of without TEP. Open arrowheads, OPN immunostained-positive cells in the mucosa. Bars in the image indicate 50 µm. n=3–9. *P<0.05 vs control for each category. TEP attenuated the excessive NO via NOS2 levels, and promote recovery from IMC-induced ileal ulcerogenic lesions in AA rats