Effect of rapid cefpodoxime disk screening for early detection of third-generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae bacteremia

Table 3 Antimicrobial prescription protocol when 3rd generation cephalosporin resistance is determined by CPDX screening results

Cases	Recommendations
Antimicrobials administered
Carbapenems	Continuation of antimicrobials
TAZ/PIPC, TAZ/CTLZ, Cephamycins, Oxacephems	Continuation of antimicrobials. ^a However, in severe cases such as septic shock, change to carbapenems
Aminoglycoside	Continuation of antimicrobials However, in severe cases such as septic shock and in cases other than urinary tract infection, change to carbapenems
Other antimicrobial agents	Change to carbapenems
No antimicrobials administered	Initiate carbapenems

TAZ/PIPC Tazobactam/piperacillin, TAZ/CTLZ Tazobactam/ceftolozane
^aIf the bacterial species are identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and intrinsic resistance to the administered antimicrobial agent is evident, change to an effective antimicrobial agent is suggested

ISSN: 2055-0294