Table 1 Clinical laboratory data during the treatment of vadadustat
Unit | Before the initiation of vadadustat (day -49) | At the initiation of vadadustat (day 0) | At the initiation of daprodustat (day 57) | |
|---|---|---|---|---|
Total protein | g/dL | 7.2 | 7.1 | 7.6 |
Albumin | g/dL | 3.9 | 4.1 | 4.0 |
BUN | mg/dL | 40.4 | 44.1 | 43.2 |
Creatinine | mg/dL | 1.91 | 1.79 | 1.95 |
eGFR | mL/min/1.73m2 | 28.0 | 30.1 | 27.4 |
Na | meq/L | 137 | 139 | 136 |
K | meq/L | 5.5 | 5.2 | 5.8 |
Cl | meq/L | 105 | 105 | 103 |
AST | U/L | 29 | 26 | 38 |
ALT | U/L | 25 | 23 | 38 |
LDH | U/L | 214 | 208 | 241 |
γ-GTP | U/L | 13 | 12 | 13 |
T-Bil | mg/dL | 0.3 | 0.4 | 0.4 |
Glucose | mg/dL | 118 | 130 | 94 |
CPK | U/L | 383 | 234 | 262 |
HDL-c | mg/dL | 49.2 | 54.4 | 48.9 |
LDL-c | mg/dL | 53 | 56 | 53 |
HbA1c(NGSP) | % | 7.4 | 7.4 | 7.5 |
HbF | % | 1.3 | 1.3 | 1.3 |
White blood cell | × 103/μL | 6.09 | 7.34 | 7.47 |
Red blood cell | × 103/μL | 3.26 | 3.28 | 3.43 |
Hemoglobin | g/dL | 9.8 | 9.9 | 10.4 |
Hematocrit | % | 30.8 | 30.8 | 32.7 |
MCV | fL | 94.5 | 93.9 | 95.3 |
MCH | pg | 30.1 | 30.2 | 30.3 |
MCHC | % | 31.8 | 32.1 | 31.8 |
Platelet | × 103/μL | 161 | 131 | 152 |