Table 2 Drug interaction probability scale
Question | Patient 1 |
|---|---|
1 Are there previous credible reports of this interaction in humans? | NA (0) |
2 Is the observed interaction consistent with the known interactive properties of precipitant drug? | Y (+ 1) |
3 Is the observed interaction consistent with the known interactive properties of object drug? | Y (+ 1) |
4 Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)? | Y (+ 1) |
5 Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? | Y (+ 1) |
6 Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug? | NA (0) |
7 Are there reasonable alternative causes for the event? | N (0) |
8 Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction? | NA (0) |
9 Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug? | Y (+ 1) |
10 Was the Interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased? | NA (0) |
Total scores (Causality of drug-drug interaction) | 5 (Probable) |