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Table 2B CRH/TRH/GnRH loading test on the fourth day after admission

From: Pembrolizumab-induced secondary adrenal insufficiency due to adrenocorticotrophic hormone deficiency in a patient with non-small-cell lung carcinoma: a case report

   

Time (min)

Reference range*

Basal

30

60

90

Cortisol

µg/dL

(6.2–18.0)

0.3

0.3

0.3

0.3

ACTH

pg/mL

(7.2–63.3)

< 2.0

< 2.0

< 2.0

< 2.0

TSH

µIU/mL

(0.50–5.00)

0.58

4.29

4.19

–

PRL

ng/mL

(4.0–14.0)

11.4

79.0

67.4

–

LH

µg/dL

(2.2–8.4)

9.5

35.7

41.9

39.2

FSH

mIU/mL

(1.8–12.0)

18.7

27.8

31.1

33.1

  1. Corticorelin (100 µg), protirelin (200 µg), and gonadorelin acetate (100 µg) were injected intravenously. ACTH: adrenocorticotropic hormone; CRH: corticotropin-releasing hormone; FSH: follicle-stimulating hormone; GnRH: gonadotropin-releasing hormone; LH: luteinising hormone; PRL: prolactin; TRH: thyrotropin-releasing hormone; TSH: thyroid-stimulating hormone
  2. *Basal levels