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  1. Research article

    Application of ozone gas for decontamination of nucleoside anticancer drugs

    Exposure to anticancer drugs is hazardous and may lead to chromosomal abnormalities and spontaneous abortion in healthcare workers. Guidelines recommend surface decontamination and cleaning in order to minimiz...

    Ayumi Tsukamoto, Shunji Ishiwata, Asami Kajimoto, Ryusuke Murata, Rika Kitano, Tomomi Inoue and Takeshi Kotake

    Journal of Pharmaceutical Health Care and Sciences 2016 2:26

    Published on: 4 October 2016

  2. Research article

    Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

    This study aimed to develop a simultaneous determination method for tramadol and its desmethylates in human plasma using isocratic liquid chromatography coupled to tandem mass spectrometry and to validate it f...

    Hironari Tanaka, Takafumi Naito, Yasuaki Mino and Junichi Kawakami

    Journal of Pharmaceutical Health Care and Sciences 2016 2:25

    Published on: 4 October 2016

  3. Research article

    A novel predictive factor for the onset time of docetaxel-induced onychopathy: a multicenter retrospective study

    Taxanes are known to cause onychopathy. Previous studies have reported the relationship between onychopathy and paclitaxel dosing intervals and cumulative doses. However, there are no studies of the predictive...

    Hidenobu Takahata, Kouichi Tanabe, Akiyoshi Takaki, Tsuneaki Yamanouchi, Yasuhiko Mimura, Atsumi Nitta, Hatsuna Yasuda, Tatsuhiko Kashii and Isao Adachi

    Journal of Pharmaceutical Health Care and Sciences 2016 2:24

    Published on: 29 September 2016

  4. Short report

    Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody

    Hypomagnesemia is one of the characteristic side effects of the human anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab and panitumumab.

    Toshiyasu Tsujii, Takafumi Ogaki, Kaori Nakae, Kiyotaka Imai, Daisuke Kise, Shoji Tada, Hiroki Ueda and Masahiro Moriyama

    Journal of Pharmaceutical Health Care and Sciences 2016 2:23

    Published on: 22 September 2016

  5. Research article

    Plasma tenofovir trough concentrations are associated with renal dysfunction in Japanese patients with HIV infection: a retrospective cohort study

    Plasma tenofovir (TFV) trough concentrations may be relevant for tenofovir disoproxil fumarate (TDF)-induced renal dysfunction. The purpose of this study was to determine the association between plasma TFV tro...

    Yusuke Kunimoto, Hiroshi Ikeda, Satoshi Fujii, Manabu Kitagawa, Kieko Yamazaki, Hiromasa Nakata, Norimasa Noda, Tadao Ishida and Atsushi Miyamoto

    Journal of Pharmaceutical Health Care and Sciences 2016 2:22

    Published on: 22 September 2016

  6. Research article

    Pharmaceutical studies on and clinical application of olanzapine suppositories prepared as a hospital preparation

    A new formulation of olanzapine available for terminally ill patients is needed. Rectal administration using suppositories is an alternative for patients for whom administration via the oral route is not feasi...

    Kazuaki Matsumoto, Satoru Kimura, Kenichi Takahashi, Yuta Yokoyama, Masayuki Miyazawa, Satoko Kushibiki, Morio Katamachi and Junko Kizu

    Journal of Pharmaceutical Health Care and Sciences 2016 2:20

    Published on: 21 September 2016

  7. Research article

    Evaluation of pharmaceutical lifesaving skills training oriented pharmaceutical intervention

    Many pharmacists are participating in team-based medical care in emergency hospitals. Therefore, there is a desperate need to improve the education system. In the present study, we provided a “pharmaceutical l...

    Yoshito Zamami, Toru Imai, Masaki Imanishi, Kenshi Takechi, Naoko Shiraishi, Toshihiro Koyama, Hidenori Sagara, Yasukazu Shiino, Toshiaki Sendo and Keisuke Ishizawa

    Journal of Pharmaceutical Health Care and Sciences 2016 2:21

    Published on: 7 September 2016

  8. Research article

    Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome

    Sivelestat, a neutrophil elastase inhibitor, was previously approved in Japan for the treatment of acute lung injury associated with systemic inflammatory response syndrome. However, sivelestat produced incons...

    Takuma Ozawa, Kiyoshi Mihara and Nobuhiro Yasuno

    Journal of Pharmaceutical Health Care and Sciences 2016 2:19

    Published on: 24 August 2016

  9. Research article

    Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation

    We investigated the pharmacokinetics of etoposide (ETP) to reduce the inter-individual variations of ETP concentrations in patients with acute leukemia who underwent allogeneic hematopoietic stem cell transpla...

    Yuki Tazawa, Akio Shigematsu, Kumiko Kasashi, Junichi Sugita, Tomoyuki Endo, Takeshi Kondo, Takanori Teshima, Ken Iseki, Mitsuru Sugawara and Yoh Takekuma

    Journal of Pharmaceutical Health Care and Sciences 2016 2:18

    Published on: 8 August 2016

  10. Research article

    Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

    Catheter ablation is a non-medication therapy for atrial fibrillation, and during the procedure, warfarin is withdrawn in the preoperative period to prevent the risk of bleeding. In case of emergency, vitamin K2 ...

    Zhi Zhou, Ikuko Yano, Sumiko Odaka, Yosuke Morita, Satoshi Shizuta, Mamoru Hayano, Takeshi Kimura, Akinori Akaike, Ken-ichi Inui and Kazuo Matsubara

    Journal of Pharmaceutical Health Care and Sciences 2016 2:17

    Published on: 4 August 2016

  11. Research article

    Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population

    Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.

    Aya Goto, Haruka Kotani, Masayuki Miyazaki, Kiyofumi Yamada, Kazuhiro Ishikawa, Yasuhiko Shimoyama, Toshimitsu Niwa, Yoshinori Hasegawa and Yukihiro Noda

    Journal of Pharmaceutical Health Care and Sciences 2016 2:16

    Published on: 21 July 2016

  12. Case report

    Elevated prothrombin time/international normalized ratio associated with concurrent administration of regorafenib and warfarin in a patient with advanced colorectal cancer

    Regorafenib and its metabolites may inhibit the activities of several CYP or UDP-glucuronosyltransferase isoforms, including that of CYP2C9. Therefore, pharmacological agents that are CYP2C9 substrates may sho...

    Hironori Kitade, Azusa Hiromasa-Yamasaki, Kengo Hokkoku, Mitsue Mori, Michio Watanabe, Masuo Nakai and Seiji Yano

    Journal of Pharmaceutical Health Care and Sciences 2016 2:15

    Published on: 8 July 2016

  13. Research article

    Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions associated with fatal disorders. Although many causes of SJS/TEN have been proposed, the time-to-onset...

    Junko Abe, Ryogo Umetsu, Kanako Mataki, Yamato Kato, Natsumi Ueda, Yoko Nakayama, Yuuki Hane, Toshinobu Matsui, Haruna Hatahira, Sayaka Sasaoka, Yumi Motooka, Hideaki Hara, Zenichiro Kato, Yasutomi Kinosada, Naoki Inagaki and Mitsuhiro Nakamura

    Journal of Pharmaceutical Health Care and Sciences 2016 2:14

    Published on: 21 June 2016

  14. Research article

    Preliminary study for predicting better methotrexate efficacy in Japanese patients with rheumatoid arthritis

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammatory status, joint destruction, disability, and pain. Methotrexate (MTX) has been confirmed to reduce disease activit...

    Masayuki Hashiguchi, Tomomi Tsuru, Kumika Miyawaki, Midori Suzaki, Jun Hakamata, Mikiko Shimizu, Shin Irie and Mayumi Mochizuki

    Journal of Pharmaceutical Health Care and Sciences 2016 2:13

    Published on: 7 June 2016

  15. Research article

    The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study

    We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers.

    Shuichi Nawata, Noriko Kohyama, Naoki Uchida, Satoshi Numazawa, Masayuki Ohbayashi, Yasuna Kobayashi, Masanori Iwata, Takanori Nakajima, Hiroshi Saito, Akira Izuka and Toshinori Yamamoto

    Journal of Pharmaceutical Health Care and Sciences 2016 2:12

    Published on: 17 May 2016

  16. Research article

    Instructing students to measure their own bone density and prepare a simulated health class during pharmacy school improves their awareness and understanding of osteoporosis prevention

    Osteoporosis is estimated to afflict over 200 million people worldwide and healthcare professionals are needed to successfully intervene. The aim of this study was to assess cognitive changes in students perta...

    Erisa Tomishige-Mukai, Akio Kawachi, Erika Kiyohara, Fuminori Esaki, Junichiro Sonoda, Tomohiro Shinya, Keiko Narumi, Keizo Sato and Toshiro Motoya

    Journal of Pharmaceutical Health Care and Sciences 2016 2:11

    Published on: 3 May 2016

  17. Research article

    A retrospective analysis of patient-specific factors on voriconazole clearance

    Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables a...

    Satoshi Dote, Maki Sawai, Ayumu Nozaki, Kazumasa Naruhashi, Yuka Kobayashi and Hirokazu Nakanishi

    Journal of Pharmaceutical Health Care and Sciences 2016 2:10

    Published on: 19 April 2016

  18. Research article

    Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

    This study was designed to evaluate the population pharmacokinetics (popPK) of penicillin G in patients with infective endocarditis and establish a dosage regimen based on pharmacokinetic data and clinical out...

    Toshiaki Komatsu, Takayuki Inomata, Ichiro Watanabe, Masahiro Kobayashi, Hideya Kokubun, Junya Ako and Koichiro Atsuda

    Journal of Pharmaceutical Health Care and Sciences 2016 2:9

    Published on: 5 April 2016

  19. Research article

    Effect of high-potency statins on HbA1c in patients with or without diabetes mellitus

    The increased risk of new-onset diabetes with statin use, including high-potency statins, is well known. However, the effects of high-potency statins on HbA1c are unclear. A retrospective cohort study was cond...

    Nobuhiro Ooba, Shoutarou Tanaka, Yu Yasukawa, Nariyasu Yoshino, Hiroyuki Hayashi, Shinji Hidaka, Toshiichi Seki and Noriyasu Fukuoka

    Journal of Pharmaceutical Health Care and Sciences 2016 2:8

    Published on: 18 March 2016

  20. Short report

    Performance characteristics between TDx®FLx and TBA™-25FR for the therapeutic drug monitoring of methotrexate

    High-dose methotrexate (HDMTX) is used in the treatment of certain malignancies, including leptomeningeal metastases, systemic non-Hodgkin lymphoma, acute lymphoblastic leukemia, and osteosarcoma. High circula...

    Tetsuya Kaneko, Takashi Fujioka, Yosuke Suzuki, Yuhki Sato and Hiroki Itoh

    Journal of Pharmaceutical Health Care and Sciences 2016 2:7

    Published on: 8 March 2016

  21. Research article

    Feasibility study of short hydration using oral rehydration solution in cisplatin including chemotherapy of lung cancer

    Cisplatin (CDDP) is used as a key anticancer drug for solid cancers, including lung cancer. However, a large quantity of fluid replacement is required to prevent renal dysfunction. This requirement have made o...

    Junya Sato, Naoto Morikawa, Hiroo Nitanai, Hiromi Nagashima, Satoru Nihei, Kohei Yamauti and Kenzo Kudo

    Journal of Pharmaceutical Health Care and Sciences 2016 2:6

    Published on: 5 March 2016

  22. Short report

    Assessment of drug content uniformity of atropine sulfate triturate by liquid chromatography–tandem mass spectrometry, X-ray powder diffraction, and Raman chemical imaging

    Atropine sulfate is an anticholinergic agent for treatment of hypertrophic pyloric stenosis and is orally administrated as a triturate with lactose hydrate. Because of the low safety margin of atropine sulfate...

    Kei Moriyama, Yoichiro Takami, Natsuki Uozumi, Akiko Okuda, Mayumi Yamashita, Rie Yokomizo, Kenichi Shimada, Takashi Egawa, Takehito Kamei and Kazunobu Takayanagi

    Journal of Pharmaceutical Health Care and Sciences 2016 2:4

    Published on: 10 February 2016

  23. Research article

    Risk of major bleeding at different PT-INR ranges in elderly Japanese patients with non-valvular atrial fibrillation receiving warfarin: a nested case-control study

    Debate continues about the optimal anticoagulation level for elderly Japanese patients with non-valvular atrial fibrillation (NVAF) receiving warfarin. The Japanese Circulation Society guideline has recommende...

    Atsushi Ohgushi, Takayuki Ohtani, Natsumi Nakayama, Shigeo Asai, Yoshiyuki Ishii, Atsuo Namiki, Manabu Akazawa and Hirotoshi Echizen

    Journal of Pharmaceutical Health Care and Sciences 2016 2:2

    Published on: 11 January 2016

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