Table 4 Incidence of adverse drug reactions
Adverse drug reactions | Intervention group (n = 31) n (%) | Non-intervention group (n = 39) n (%) | P-value (Any) | ||
|---|---|---|---|---|---|
Grade | Any | 3 ~ 4 | Any | 3 ~ 4 |  |
Hand-foot skin reactiona | 23(74.2) | 2(6.5) | 19(48.7) | 3(7.7) | 0.049* |
Diarrhea | 21(67.7) | 2(6.5) | 5(12.8) | 1(2.6) | < 0.001** |
Hypertension | 16(51.6) | 6(19.4) | 15(38.5) | 5(12.5) | 0.336 |
Anorexia | 15(48.4) | 1(3.2) | 6(15.4) | - | 0.002** |
Hair loss | 13(41.9) | - | 5(12.8) | - | 0.012* |
Thrombocytopenia | 11(35.5) | 2(6.5) | 4(10.3) | 3(7.7) | 0.018* |
AST increased | 11(35.5) | 5(16.1) | 6(15.4) | 3(7.7) | 0.091 |
Hoarseness | 10(32.3) | - | 4(10.3) | - | 0.034* |
ALT increased | 9(29.0) | - | 6(15.4) | 3(7.7) | 0.242 |
Serum amylase increased | 9(29.0) | 6(19.4) | 3(7.7) | 1(2.6) | 0.026* |
Fatigue | 7(22.6) | - | 1(2.6) | - | 0.018* |
Stomatitis | 6(19.4) | - | 1(2.6) | - | 0.039* |
Hypothyroidism | 5(16.1) | - | 3(7.7) | - | 0.452 |
Blood bilirubin increased | 5(16.1) | 1(3.2) | 3(7.7) | 1(2.6) | 0.452 |
Rash maculo-papular | 4(12.9) | - | 4(10.3) | - | 1.000 |