Characteristic a | Changed to generic (n = 135) | Continued brand (n = 147) | P value |
---|---|---|---|
Gender | |||
Male | 78 (57.8) | 84 (57.1) | 0.914 |
Female | 57 (42.2) | 63 (42.9) | |
Age | 53 (27 ~ 73) | 52 (25 ~ 72) | 0.383 |
Prescribing medical establishment | |||
Clinic | 83 (61.5) | 111 (75.5) | <0.05 |
Hospital | 52 (38.5) | 36 (24.5) | |
Type of prescriber | |||
General practitioner | 51 (37.8) | 59 (40.1) | |
Cardiologist | 5 (3.7) | 3 (2.0) | 0.841 |
Others | 79 (58.5) | 85 (5708) | |
Comorbidities | |||
Depression | 5 (3.7) | 9 (6.1) | 0.351 |
Cardiac disease | 17 (12.6) | 23 (15.6) | 0.463 |
Cerebrovascular disease | 18 (13.3) | 15 (10.2) | 0.415 |
Hypertension | 71 (52.6) | 55 (37.4) | <0.05 |
Diabetes mellitus | 63 (46.7) | 55 (37.4) | 0.116 |
Cancer | 21 (15.6) | 22 (15.0) | 0.891 |
Peripheral vascular disease | 10 (7.4) | 10 (6.8) | 0.844 |
Arrhythmia | 0 | 8 (5.4) | <0.01 |
Renal dysfunction | 1 (0.7) | 1 (0.7) | 0.729 |
Dementia | 0 | 1 (0.7) | 0.521 |
Charlson comorbidity index | 1.0 (0 ~ 12) | 1.0 (0 ~ 13) | 0.698 |
Total number of drugs prescribed | 3 (1~25) | 2 (1~26) | 0.870 |
Other mediation for cardiovascular disease | |||
inotropic agent | 1 (0.7) | 2 (1.4) | 0.532 |
Antiarrhythmic agent | 1 (0.7) | 1 (0.7) | 0.729 |
Diuretics | 6 (4.4) | 6 (4.1) | 0.880 |
β-Blocker | 6 (4.4) | 7 (4.8) | 0.899 |
Calcium channel blocker | 30 (22.2) | 11 (7.5) | < 0.01 |
ACE inhibitor | 1 (0.7) | 1 (0.7) | 0.729 |
Angiotensin II receptor antagonist | 32 (23.7) | 25 (17.0) | 0.162 |
Direct Renin Inhibitor | 0.0 | 1 (0.7) | 0.521 |
Platelet aggregation inhibitor | 9 (6.7) | 16 (10.9) | 0.213 |
Daily dosage of atorvastatin | |||
2.5 mg | 1 (0.7) | 0 | |
5 mg | 66 (48.9) | 61 (41.5) | |
10 mg | 68 (50.4) | 82 (55.8) | 0.224 |
15 mg | 0 | 2 (1.4) | |
20 mg | 0 | 1 (0.7) | |
30 mg | 0 | 1 (0.7) | |
Duration of use of atorvastatin prior to index date b | 126 (10~332) | 98 (14~229) | < 0.05 |