Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports

Kato, Yamato; Umetsu, Ryogo; Abe, Junko; Ueda, Natsumi; Nakayama, Yoko; Kinosada, Yasutomi; Nakamura, Mitsuhiro

doi:10.1186/s40780-015-0015-6

Journal of Pharmaceutical Health Care and Sciences

Table 3 Preferred terms associated with adverse hyperglycemia in the Standardized MedDRA Queries (SMQ; 20000041)

From: Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports

Preferred terms	Code	Total	Atypical		Typical
			Cases ^*	Reporting ratio (%)	Cases ^*	Reporting ratio (%)
Total		241478	21151	8.8	3948	1.6
Abnormal loss of weight	10000159	532	28	5.3	9	1.7
Abnormal weight gain	10000188	134	33	24.6	0	0
Acidosis	10000486	1956	102	5.2	44	2.2
Altered state of consciousness	10001854	3306	303	9.2	111	3.4
Anti-GAD antibody positive	10059728	23	2	8.7	0	0
Anti-insulin antibody increased	10053815	51	0	0	0	0
Anti-insulin antibody positive	10053814	115	0	0	0	0
Anti-insulin receptor antibody increased	10068226	0	0	0	0	0
Anti-insulin receptor antibody positive	10068225	3	0	0	0	0
Anti-islet cell antibody positive	10049439	4	1	25	0	0
Blood 1,5-anhydroglucitol decreased	10065367	0	0	0	0	0
Blood cholesterol increased	10005425	10887	1648	15.1	63	0.6
Blood glucose abnormal	10005554	1547	116	7.5	12	0.8
Blood glucose fluctuation	10049803	2267	76	3.4	6	0.3
Blood glucose increased	10005557	35838	1398	3.9	241	0.7
Blood insulin abnormal	10005606	7	0	0	0	0
Blood insulin decreased	10005613	23	1	4.3	1	4.3
Blood lactic acid increased	10005635	826	47	5.7	6	0.7
Blood osmolarity increased	10005697	112	16	14.3	3	2.7
Blood triglycerides increased	10005839	5404	1199	22.2	35	0.6
Body mass index decreased	10005895	59	14	23.7	0	0
Body mass index increased	10005897	112	29	25.9	0	0
Central obesity	10065941	81	7	8.6	1	1.2
Coma	10010071	10703	1018	9.5	253	2.4
Dehydration	10012174	27804	1067	3.8	1025	3.7
Depressed level of consciousness	10012373	10200	819	8	333	3.3
Diabetes complicating pregnancy	10012596	3	1	33.3	0	0
Diabetes mellitus	10012601	15780	5523	35	98	0.6
Diabetes mellitus inadequate control	10012607	3689	825	22.4	25	0.7
Diabetes with hyperosmolarity	10012631	27	8	29.6	0	0
Diabetic coma	10012650	1045	551	52.7	1	0.1
Diabetic hepatopathy	10071265	0	0	0	0	0
Diabetic hyperglycaemic coma	10012668	80	7	8.8	1	1.3
Diabetic hyperosmolar coma	10012669	170	66	38.8	7	4.1
Diabetic ketoacidosis	10012671	2725	1090	40	26	1
Diabetic ketoacidotic hyperglycaemic coma	10012672	32	6	18.8	0	0
Fructosamine increased	10017395	5	0	0	0	0
Gestational diabetes	10018209	594	140	23.6	15	2.5
Glucose tolerance decreased	10018428	13	0	0	0	0
Glucose tolerance impaired	10018429	1058	260	24.6	6	0.6
Glucose tolerance impaired in pregnancy	10018430	3	1	33.3	0	0
Glucose tolerance test abnormal	10018433	36	3	8.3	0	0
Glucose urine present	10018478	318	23	7.2	15	4.7
Glycosuria	10018473	384	140	36.5	5	1.3
Glycosuria during pregnancy	10018475	1	0	0	0	0
Glycosylated haemoglobin increased	10018484	2569	171	6.7	11	0.4
Hunger	10020466	1575	142	9	8	0.5
Hypercholesterolaemia	10020603	2210	256	11.6	26	1.2
Hyperglycaemia	10020635	7844	1382	17.6	129	1.6
Hyperglycaemic hyperosmolar nonketotic syndrome	10063554	184	98	53.3	7	3.8
Hyperglycaemic seizure	10071394	5	0	0	0	0
Hyperglycaemic unconsciousness	10071286	10	0	0	0	0
Hyperlactacidaemia	10020660	333	13	3.9	5	1.5
Hyperlipidaemia	10062060	4585	747	16.3	45	1
Hyperosmolar state	10020697	113	24	21.2	3	2.7
Hyperphagia	10020710	632	157	24.8	4	0.6
Hypertriglyceridaemia	10020869	1127	154	13.7	14	1.2
Hypoglycaemia	10020993	10839	672	6.2	99	0.9
Hypoinsulinaemia	10070070	1	0	0	0	0
Impaired fasting glucose	10056997	67	22	32.8	0	0
Impaired insulin secretion	10052341	21	0	0	0	0
Increased appetite	10021654	2646	494	18.7	21	0.8
Increased insulin requirement	10021664	31	2	6.5	0	0
Insulin autoimmune syndrome	10022472	23	0	0	0	0
Insulin resistance	10022489	297	75	25.3	0	0
Insulin resistance syndrome	10022490	18	6	33.3	0	0
Insulin resistant diabetes	10022491	27	8	29.6	0	0
Insulin tolerance test abnormal	10022494	3	0	0	0	0
Insulin-requiring type 2 diabetes mellitus	10053247	122	60	49.2	0	0
Ketoacidosis	10023379	640	250	39.1	3	0.5
Ketonuria	10023388	188	63	33.5	5	2.7
Ketosis	10023391	100	13	13	3	3
Lactic acidosis	10023676	4561	119	2.6	61	1.3
Latent autoimmune diabetes in adults	10066389	16	0	0	0	0
Lipids increased	10024592	368	57	15.5	1	0.3
Loss of consciousness	10024855	28249	1750	6.2	355	1.3
Metabolic acidosis	10027417	5512	253	4.6	121	2.2
Metabolic syndrome	10052066	392	197	50.3	2	0.5
Neonatal diabetes mellitus	10028933	3	0	0	1	33.3
Obesity	10029883	2787	1211	43.5	23	0.8
Overweight	10033307	442	114	25.8	3	0.7
Pancreatogenous diabetes	10033660	6	2	33.3	0	0
Polydipsia	10036067	1026	271	26.4	16	1.6
Polyuria	10036142	1444	197	13.6	27	1.9
Slow response to stimuli	10041045	161	37	23	7	4.3
Thirst	10043458	2595	224	8.6	40	1.5
Type 1 diabetes mellitus	10067584	1252	590	47.1	7	0.6
Type 2 diabetes mellitus	10067585	5272	2862	54.3	16	0.3
Underweight	10048828	111	8	7.2	2	1.8
Unresponsive to stimuli	10045555	5657	442	7.8	123	2.2
Urine ketone body present	10057597	304	31	10.2	13	4.3
Weight decreased	10047895	42275	1765	4.2	466	1.1
Weight increased	10047899	30417	5070	16.7	867	2.9

*With adverse events of interest.

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