Fig. 1

Systolic blood pressure changes in SHR after single oral administration. Systolic blood pressure changes in SHR after single oral administration of (a) enalapril (3.0 mg/kg, ■), FMP (VPP, IPP: 3.5 mg/kg, ▲), or concomitant enalapril (3.0 mg/kg) and FMP (VPP, IPP: 3.5 mg/kg, ●); (b) enalapril (3.0 mg/kg, ■), FMP (VPP, IPP: 1.75 mg/kg, ▲), or concomitant enalapril (3.0 mg/kg) and FMP (VPP, IPP: 1.75 mg/kg, ●); (c) enalapril (3.0 mg/kg, ■), FPP (LKPNM: 10 mg/kg, ▲), or concomitant enalapril (3.0 mg/kg) and FPP (LKPNM: 10 mg/kg, ●). The control group (◆) received distilled water. Values are presented as the mean ± SE (n = 4). *p < 0.05 vs enalapril monotherapy group; ^✢p < 0.05; ^✢✢p < 0.01 vs the control group at the same time point (Bonferroni/Dunn, Scheffe’s F test)