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Table 1 Patient characteristics

From: Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients

Number of Patients 192
Gender (Male:Female) 121:71
EF (%) (>=40: <40) 156:36
Age (year) 71±12*
CLcr (mL/min) 56.17±33.76*
Weight (kg) 55.47±11.94*
Observation 287
0.125 mg /3 days 7
0.125 mg /2 days 17
0.0625 mg /day 14
0.125 mg/day 200
0.25 mg/day 49
Digoxin concentration (ng/mL) 0.90±0.56*
Combination medication  
Amiodarone 15
Amlodipine 21
Atorvastatin 14
Azelnidipine 13
Bisoprolol 28
Carvedilol 53
Nifedipine 13
Spironolactone 35
Tolvaptan 8
Antiarrhythmic agent; Class I 12
(Aprindine, Cibenzoline, Flecainide, Pilsicainde, Procainamide)
Antiarrhythmic agent;Class IV 31
(Bepridil, Diltiazem, Verapamil)  
  1. *Mean ± standerd deviation
  2. EF; Ejunction function, CLcr; Creatine clearance