Table 1 Patient characteristics
From: Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients
Number of Patients | 192 |
Gender (Male:Female) | 121:71 |
EF (%) (>=40: <40) | 156:36 |
Age (year) | 71±12* |
CLcr (mL/min) | 56.17±33.76* |
Weight (kg) | 55.47±11.94* |
Observation | 287 |
0.125 mg /3 days | 7 |
0.125 mg /2 days | 17 |
0.0625 mg /day | 14 |
0.125 mg/day | 200 |
0.25 mg/day | 49 |
Digoxin concentration (ng/mL) | 0.90±0.56* |
Combination medication | |
Amiodarone | 15 |
Amlodipine | 21 |
Atorvastatin | 14 |
Azelnidipine | 13 |
Bisoprolol | 28 |
Carvedilol | 53 |
Nifedipine | 13 |
Spironolactone | 35 |
Tolvaptan | 8 |
Antiarrhythmic agent; Class I | 12 |
(Aprindine, Cibenzoline, Flecainide, Pilsicainde, Procainamide) | |
Antiarrhythmic agent;Class IV | 31 |
(Bepridil, Diltiazem, Verapamil) | |