From: Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients
Population mean parameters | |
CL(L/h)= (1.21+0.0532×CLcr(mL/min)) ×(1+0.787×AMD) | |
(AMD = 0 for cocomitant adminstarion of amiodarone, otherwise 1) | |
Interindividual variance | |
ω(CL)=32.2 % | |
Intraindividual variance | |
σ=25.5 % |