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Table 4 Results of bootstrap validation

From: Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients

Parameter Final Modela Bootstrapb 95% Confidence interval
  Mean ± S.E. Mean ± S.E. [Lower, Upper]
θ1 1.21 ± 0.21 1.30 ± 0.05 [1.20-1.39]
θ2 0.0532 ± 0.0068 0.0543 ± 0.0016 [0.050-0.057]
θ3 0.787 ± 0.187 0.803 ± 0.018 [0.768-0.838]
ωCL 0.104 ± 0.017 0.324 ± 0.006 [0.312-0.336]
σ 0.065 ± 0.010 0.340 ± 0.086 [0.171-0.509]
  1. CL=(θ1+θ2×CLcr)×(1+θ3×AMD)
  2. a Obtained from the original data set
  3. b Calculated from 200 bootstrap replicates(180 convergence)