Table 4 Results of bootstrap validation
From: Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients
Parameter | Final Modela | Bootstrapb | 95% Confidence interval |
|---|---|---|---|
Mean ± S.E. | Mean ± S.E. | [Lower, Upper] | |
θ1 | 1.21 ± 0.21 | 1.30 ± 0.05 | [1.20-1.39] |
θ2 | 0.0532 ± 0.0068 | 0.0543 ± 0.0016 | [0.050-0.057] |
θ3 | 0.787 ± 0.187 | 0.803 ± 0.018 | [0.768-0.838] |
ωCL | 0.104 ± 0.017 | 0.324 ± 0.006 | [0.312-0.336] |
σ | 0.065 ± 0.010 | 0.340 ± 0.086 | [0.171-0.509] |