Fig. 3From: Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomesLong-term changes of CYP3A4 activity and serum clarithromycin or its metabolite concentrations. Time course of serum concentration of clarithromycin (CAM, ○) and 14-hydroxy-CAM (M-5, △), and the ratio of urinary 6β-hydroxycortisol/cortisol (6βOHF/F, ♦) up to the day 365 (n = 4, mean ± SE)Back to article page