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Table 2 Pharmacokinetic parameters calculated by non-compartmental analysis

From: PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

Patient AUC0→ τ , plasma(mg・hr/L) AUC0→ τ , FD(mg・hr/L) SC CLtot(L/hr) Vdss(L) Cmax, plasma(μg/mL) Cmax, FD(μg/mL) T1/2, plasma(hr) T1/2, FD(hr)
A 37.7 37.6 1.00 7.96 0.33 11.92 11.29 3.99 3.20
B 72.4a 79.7a 1.10 4.14 0.46 15.93 12.09 3.97 5.43
C 63.2 61.2 0.97 4.75 0.30 20.08 19.43 3.42 3.62
D 31.4 29.9 0.95 9.54 0.35 12.15 9.13 2.05 2.20
E 54.3 55.3 1.02 5.53 0.33 19.42 19.55 2.83 2.73
F 32.2 29.9 0.93 9.32 0.24 23.93 15.37 1.38 1.25
G 78.2 79.6 1.02 3.84 0.17 25.80 24.24 3.39 3.66
Mean    1.00 6.44 0.31    3.00 3.15
SD    0.06 2.45 0.09    0.99 1.31
  1. AUC 0→ τ , plasma area under the plasma concentration-time curve from time 0 to next infusion; AUC 0→ τ , FD area under the filtrate-dialysate concentration-time curve from time 0 to next infusion; SC sieving coefficient (AUC0→ τ , FD/AUC0→ τ , Plasma); CL tot total clearance (300/AUC0→τ, plasma); Vd ss volume of distribution at the steady state; C max,plasma maximum concentration of BIPM in plasma; C max, FD maximum concentration of BIPM in filtrate-dialysate; T 1/2, plasma elimination half-life of BIPM in plasma; T 1/2, FD elimination half-life of BIPM in filtrate-dialysate; SD standard deviation
  2. aAUC0→∞