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Table 2 Pharmacokinetic parameters calculated by non-compartmental analysis

From: PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

Patient

AUC0→ τ , plasma(mg・hr/L)

AUC0→ τ , FD(mg・hr/L)

SC

CLtot(L/hr)

Vdss(L)

Cmax, plasma(μg/mL)

Cmax, FD(μg/mL)

T1/2, plasma(hr)

T1/2, FD(hr)

A

37.7

37.6

1.00

7.96

0.33

11.92

11.29

3.99

3.20

B

72.4a

79.7a

1.10

4.14

0.46

15.93

12.09

3.97

5.43

C

63.2

61.2

0.97

4.75

0.30

20.08

19.43

3.42

3.62

D

31.4

29.9

0.95

9.54

0.35

12.15

9.13

2.05

2.20

E

54.3

55.3

1.02

5.53

0.33

19.42

19.55

2.83

2.73

F

32.2

29.9

0.93

9.32

0.24

23.93

15.37

1.38

1.25

G

78.2

79.6

1.02

3.84

0.17

25.80

24.24

3.39

3.66

Mean

  

1.00

6.44

0.31

  

3.00

3.15

SD

  

0.06

2.45

0.09

  

0.99

1.31

  1. AUC 0→ τ , plasma area under the plasma concentration-time curve from time 0 to next infusion; AUC 0→ τ , FD area under the filtrate-dialysate concentration-time curve from time 0 to next infusion; SC sieving coefficient (AUC0→ τ , FD/AUC0→ τ , Plasma); CL tot total clearance (300/AUC0→τ, plasma); Vd ss volume of distribution at the steady state; C max,plasma maximum concentration of BIPM in plasma; C max, FD maximum concentration of BIPM in filtrate-dialysate; T 1/2, plasma elimination half-life of BIPM in plasma; T 1/2, FD elimination half-life of BIPM in filtrate-dialysate; SD standard deviation
  2. aAUC0→∞