PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

Table 3 Pharmacokinetic parameters of biapenem after intravenous administration of biapenem (300 mg) during CHDF

Patient	V ₁ (L)	k ₁₂ (hr⁻¹)	k ₂₁ (hr⁻¹)	k ₁₀ (hr⁻¹)	k ₁₃ (hr⁻¹)	CL_CHDF (L/hr)	CL_non-CHDF (L/hr)
A	11.09	2.26	1.10	0.56	0.14	1.53	6.24
B	17.45	0.33	0.66	0.15	0.09	1.65	2.54
C	9.51	0.74	0.92	0.33	0.16	1.55	3.11
D	23.84	0.18	1.13	0.34	0.06	1.43	8.04
E	11.74	0.26	0.51	0.33	0.14	1.63	3.93
F	10.19	0.69	1.08	0.78	0.14	1.39	7.92
G	10.43	0.79	1.25	0.22	0.15	1.53	2.27
Mean	13.46	0.75	0.95	0.39	0.13	1.53	4.86
SD	5.29	0.71	0.27	0.22	0.04	0.10	2.50

V ₁ Volume of distribution of central compartment; k ₁₂ transfer rate constant from central compartment to peripheral compartment; k ₂₁ transfer rate constant from peripheral compartment to central compartment; k ₁₀ elimination rate constant from central compartment; k ₁₃ transfer rate constant from central compartment to filtrate-dialysate side compartment (Q_F + Q_D) · SC/V ₁; CL _CHDF clearance by CHDF (Q_F + Q_D) · SC; CL _non-CHDF clearance by non-CHDF routes (k ₁₀ · V ₁); SD standard deviation

ISSN: 2055-0294