Skip to main content

Table 3 Pharmacokinetic parameters of biapenem after intravenous administration of biapenem (300 mg) during CHDF

From: PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration

Patient V 1 (L) k 12 (hr−1) k 21 (hr−1) k 10 (hr−1) k 13 (hr−1) CLCHDF (L/hr) CLnon-CHDF (L/hr)
A 11.09 2.26 1.10 0.56 0.14 1.53 6.24
B 17.45 0.33 0.66 0.15 0.09 1.65 2.54
C 9.51 0.74 0.92 0.33 0.16 1.55 3.11
D 23.84 0.18 1.13 0.34 0.06 1.43 8.04
E 11.74 0.26 0.51 0.33 0.14 1.63 3.93
F 10.19 0.69 1.08 0.78 0.14 1.39 7.92
G 10.43 0.79 1.25 0.22 0.15 1.53 2.27
Mean 13.46 0.75 0.95 0.39 0.13 1.53 4.86
SD 5.29 0.71 0.27 0.22 0.04 0.10 2.50
  1. V 1 Volume of distribution of central compartment; k 12 transfer rate constant from central compartment to peripheral compartment; k 21 transfer rate constant from peripheral compartment to central compartment; k 10 elimination rate constant from central compartment; k 13 transfer rate constant from central compartment to filtrate-dialysate side compartment (QF + QD) · SC/V 1; CL CHDF clearance by CHDF (QF + QD) · SC; CL non-CHDF clearance by non-CHDF routes (k 10 · V 1); SD standard deviation