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Table 2 Renal function and prescribed doses

From: Opioid analgesics increase incidence of somnolence and dizziness as adverse effects of pregabalin: a retrospective study

CLCr (mL/min) N Median of initial dose (mg/day, range) Defined initial dose (mg/day) Developed adverse effects Developed adverse effects with over defined initial dose
>60 127 150 (25–450) 150 41 (32.3 %) 1 (2.4 %)
>30–≤60 55 75 (25–150) 75 17 (30.9 %) 8 (47.1 %)
≤30 13 50 (25–150) 25 or 50 5 (38.5 %) 2 (40.0 %)