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Table 1 Clinical characteristics of case and control patients

From: Risk of major bleeding at different PT-INR ranges in elderly Japanese patients with non-valvular atrial fibrillation receiving warfarin: a nested case-control study

Characteristics Cases (n = 32) Controls (n = 64) P value
Age (yr), mean ± SD 81 ± 5 81 ± 5 NS
Gender, M/F 14/18 28/36 NS
PT-INR    
Median PT-INR(Q1,Q3) 2.62 (1.97, 5.30) 1.75 (1.52, 2.14) <0.05
≤1.49, n (%) 5 (16) 15 (24) NS
1.50 to 1.99, n (%) 3 (9) 29 (45) <0.05
2.00 to 2.49, n (%) 5 (16) 13 (20) NS
2.50 to 2.99, n (%) 4 (12) 6 (9) NS
≥3.00, n (%) 15 (47) 1 (2) <0.05
eGFR (mL/min/1.73 m2), mean ± SD 43 ± 27 49 ± 15 NS
CHADS2 score, mean ± SD 3 ± 1 3 ± 1 NS
Congestive heart failure, n (%) 19 (59) 19 (30) <0.05
Hypertension, n (%) 22 (69) 50 (78) NS
Diabetes, n (%) 5 (16) 21 (33) NS
Stroke/TIA, n (%) 16 (50) 23 (36) NS
HAS-BLED score, mean ± SD 3 ± 1 3 ± 1 NS
Impaired renal function, n (%) 7 (22) 3 (5) <0.05
Impaired liver function, n (%) 4 (13) 3 (5) NS
Stroke, n (%) 14 (44) 22 (34) NS
History of bleeding, n (%) 10 (31) 14 (22) NS
Labile PT-INR, n (%) 2 (6) 19 (30) NS
Antiplatelet or NSAID, n (%) 12 (38) 24 (38) NS
Alcohol consumption, n (%) 1 (3) 4 (6) NS
  1. Q1 and 3 represent the upper limits of the first and third interquartile ranges. TIA transient ischemic attack, PT-INR prothrombin time-international normalized ratio, eGFR estimated glomerular filtration rate, NSAID non-steroidal anti-inflammatory drug