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Table 3 Hypothesis testing for fixed effect model on penicillin G pharmacokinetics

From: Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

Fixed model OBJ −2.l.l.d p-value
CL = θ1 356.307   
θ1 + θ2 × CLcr 239.004 117.303 <0.001
θ1 + θ2 × 1/sCr 280.388 75.919 <0.001
θ1 + θ2 × BW 323.407 32.9 <0.001
θ1 × θ2ALT (ALT > 40 = 0,ALT < 40 = 1) 337.037 19.27 <0.001
θ1 × θ2sex (Male = 1,Female = 0) 324.973 31.334 <0.001
θ1 × θ2Age (Age > 65 = 1,Age < 64 = 0) 347.699 8.608 <0.005
Vd = θ3    
θ3 + θ4 × BW 356.307 0 N.S.
  1. N.S not significant, CLcr creatinine clearance, ALT alanine aminotransferase, BW body weight