Table 3 Hypothesis testing for fixed effect model on penicillin G pharmacokinetics

CL = θ1

356.307

θ1 + θ2 × CLcr

239.004

117.303

<0.001

θ1 + θ2 × 1/sCr

280.388

75.919

<0.001

θ1 + θ2 × BW

323.407

32.9

<0.001

θ1 × θ2^ALT (ALT > 40 = 0,ALT < 40 = 1)

337.037

19.27

<0.001

θ1 × θ2^sex (Male = 1,Female = 0)

324.973

31.334

<0.001

θ1 × θ2^Age (Age > 65 = 1,Age < 64 = 0)

347.699

8.608

<0.005

Vd = θ3

θ3 + θ4 × BW

356.307

0

N.S.