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Table 5 Final population pharmacokinetic parameters of penicillin G

From: Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

Parameter Estimate RSE (covariance step) 95 % CI (bootstrap method)
Population mean    
CL (L/h) = θ1 × CLcr (mL/min)    
θ1 0.21 8.81 % 0.171–0.249
Vd (L) = θ2    
θ2 28.9 8.58 % 23.4‐34.7
Interindividual variability    
ηCL 0.0835 33.1 % 0.0171‐0.1397
ηvd 0.104 5.22 % 0.0087–0.1203
Residual variability    
ε 0.0304 5.85 % 0.0265–0.0342
  1. η, random variable, which is normally distributed with mean 0 and variance ω2
  2. ε, random error, which is normally distributed with mean 0 and variance σ2
  3. RSE relative standard error, CI confidence interval, CLcr creatinine clearance