Population pharmacokinetic analysis and dosing regimen optimization of penicillin G in patients with infective endocarditis

Table 5 Final population pharmacokinetic parameters of penicillin G

Parameter	Estimate	RSE (covariance step)	95 % CI (bootstrap method)
Population mean
CL (L/h) = θ1 × CLcr (mL/min)
θ1	0.21	8.81 %	0.171–0.249
Vd (L) = θ2
θ2	28.9	8.58 %	23.4‐34.7
Interindividual variability
η_CL	0.0835	33.1 %	0.0171‐0.1397
ηvd	0.104	5.22 %	0.0087–0.1203
Residual variability
ε	0.0304	5.85 %	0.0265–0.0342

η, random variable, which is normally distributed with mean 0 and variance ω2
ε, random error, which is normally distributed with mean 0 and variance σ²
RSE relative standard error, CI confidence interval, CLcr creatinine clearance

ISSN: 2055-0294