Fig. 4

Relationships between voriconazole concentration and toxicities. A scatter plot of voriconazole concentrations from all 63 patients. Closed circles represent patients with toxicity and open circles represent patients without toxicity. Closed diamond represents patients with Grade 3 hepatotoxicity. Solid line means mean. One patient was not assessed for visual disturbance and neurotoxicity because of the administration of a sedative. Four patients were not assessed for hepatotoxicity because of liver dysfunction due to primary disease. A significant difference was seen in voriconazole mean trough concentration between patients with grade 2-3 hepatotoxicity and those without: 5.69 (SD 2.27) vs. 3.0 (SD 2.07), p < 0.001. No significant difference was seen in voriconazole mean trough concentration between patients with other adverse events and those without: visual disturbance - 3.48 (SD 1.79) vs. 3.44 (SD 2.7), p = 0.94; neurotoxicity - 4.2 (SD 2.85) vs. 3.27 (SD 2.11), p = 0.18