Fig. 2

Pharmacokinetics of 30 mg mianserin after rectal administration in healthy adult males. Closed squares represent the data from healthy adult males receiving 30 mg mianserin by rectal administration. Data show the mean ± SD, n = 3. The solid line represents the curve fitted according to the 1-compartment model with first-order absorption equation (1). In order to estimate ka and Vd, mianserin pharmacokinetic data after rectal administration were fitted to equation (1) by nonlinear least-squares regression analysis with a fixed ke value. The estimated values of ka and Vd/F were 0.146 ± 0.052 1/h (mean ± SD, n = 3) and 1395 ± 497 L, respectively