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Table 1 Genotype distribution

From: Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population

No. Gene Localization SNP Exchange N Genotype frequencies (%) MAF HWE
−/− +/− +/+
1 HTR3A 5′ UTR rs1062613 C > T 200 150 (75.0) 48 (24.0) 2 (1.0) 0.13 0.64
2 HTR3B Promotor −100_-102 AAG insertion/deletion delAAG 127 94 (74.0) 27 (21.3) 6 (4.7) - -
3 Exon 5 rs1176744 T > G 198 102 (51.5) 83 (41.9) 13 (6.6) 0.28 0.62
4 Exon 6 Ala223Thr G > A 200 200 (100) 0 (0) 0 (0) 0 -
5 HTR3C Exon 5 rs6766410 A > C 191 79 (41.4) 81 (42.4) 31 (16.2) 0.37 0.80
6 TACR1 Exon 2 Y192H T > C 200 200 (100) 0 (0) 0 (0) 0 -
7 Exon 4 rs17838409 G > A 200 200 (100) 0 (0) 0 (0) 0 -
8 DRD2 Exon 7 rs6277 C > T 200 179 (89.5) 21 (10.5) 0 (0) 0.06 0.98
9 Intron 6 rs1076560 C > A 200 76 (38.0) 95 (47.5) 29 (14.5) 0.38 1.00
10 COMT Exon 4 rs4680 G > A 197 88 (44.6) 85 (43.2) 24 (12.2) 0.34 0.87
  1. HWE Hardy-Weinberg equilibrium, MAF minor allele frequency, HTR3A serotonin 5-HT3A receptors, HTR3B serotonin 5-HT3B receptors, HTR3C serotonin 5-HT3C receptors, TACR1 tachykinin-1 receptors, DRD2 dopamine D2receptors, COMT catechol-O-methyltransferase