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Table 2 Pharmacokinetic parameters of ETP after administration at a dose of 15 mg/kg once daily over 3 h for 2 days in patients (n = 20)

From: Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation

Parameter Day 1 Day 2
Mean ± S.D. Median Range Mean ± S.D. Median Range
Cmax (μg/mL) 74.9 ± 17.0 77.4 51.8 – 116.5 77.5 ± 12.9 75.8 61.6 – 106.0
Cmin (μg/mL) 3.9 ± 2.5 3.7 0.2 – 9.1 6.2 ± 3.7 5.4 1.6 – 16.1
Vd (L/kg) 0.20 ± 0.05 0.19 0.12 – 0.29 0.20 ± 0.04 0.20 0.14 – 0.27
Kel (h–1) 0.15 ± 0.04 0.14 0.10 – 0.29 0.14 ± 0.03 0.14 0.07 – 0.20
CL (mL/h/kg) 30.9 ± 14.5 24.5 14.2 – 72.6 29.0 ± 8.5 27.4 11.3 – 45.5
AUC0-24 h or AUC24–44 h (μg・h/mL) 634 ± 154 611 423 – 1021 612 ± 126 586 424 – 852
AUC0-92 h (μg・h/mL) 1332 ± 315 1282 870 – 2015    
  1. Vd indicates volume of distribution, Kel elimination rate constant, CL clearance, AUC area under the plasma concentration–time curve