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Table 3 Pharmacokinetic parameters of ETP after intravenous administration at a dose of 15 mg/kg in rats

From: Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation

 

5 weeks (control)

7 weeks

10 weeks

 

120 – 150 g

220 – 230 g

320 – 355 g

AUC (μg・h/mL)

12.8 ± 0.33

15.8 ± 1.21*

20.4 ± 3.01*

Cmax (μg/mL)

49.0 ± 9.73

51.7 ± 4.41

71.8 ± 7.57*

Vd (L/kg)

0.32 ± 0.07

0.29 ± 0.03

0.21 ± 0.02*

Kel (h–1)

1.72 ± 0.26

1.80 ± 0.10

1.84 ± 0.38

CL (L/h/kg)

0.54 ± 0.12

0.52 ± 0.06

0.39 ± 0.10*

  1. Each value is the mean ± S.D. of 3 - 4 measurements
  2. *Significantly different from control at p <0.05
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Journal of Pharmaceutical Health Care and Sciences

ISSN: 2055-0294

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