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Table 3 Pharmacokinetic parameters of ETP after intravenous administration at a dose of 15 mg/kg in rats

From: Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation

  5 weeks (control) 7 weeks 10 weeks
  120 – 150 g 220 – 230 g 320 – 355 g
AUC (μg・h/mL) 12.8 ± 0.33 15.8 ± 1.21* 20.4 ± 3.01*
Cmax (μg/mL) 49.0 ± 9.73 51.7 ± 4.41 71.8 ± 7.57*
Vd (L/kg) 0.32 ± 0.07 0.29 ± 0.03 0.21 ± 0.02*
Kel (h–1) 1.72 ± 0.26 1.80 ± 0.10 1.84 ± 0.38
CL (L/h/kg) 0.54 ± 0.12 0.52 ± 0.06 0.39 ± 0.10*
  1. Each value is the mean ± S.D. of 3 - 4 measurements
  2. *Significantly different from control at p <0.05