Fig. 5

Effect of vitamin K₂ doses on the INR transition in the perioperative period in a typical patient with normal a or decreased renal function b. A typical patient with body weight of 50 kg was administered warfarin and vitamin K₂. In each simulation, the maintenance dose of warfarin was set to 3 mg/day and was stopped on day −1, and loading of 5 mg/day was carried out twice after catheter ablation, followed by the maintenance dose of 3 mg/day. Vitamin K₂ was administered before catheter ablation up to 3 times 20 mg each as total of 0 to 60 mg. Continuous, dashed, dash-dotted and dotted lines show the administration of 0, 20, 40 and 60 mg of vitamin K₂, respectively