Fig. 6

Effect of warfarin doses a or interindividual variability of pharmacokinetic and pharmacodynamic parameters b on INR transition in the perioperative period. In panel A, INR transitions were simulated wherein warfarin maintenance doses ranged from 3 to 6 mg without vitamin K₂ administration. Warfarin was stopped on day −1, and resumed after catheter ablation with the addition of 2 mg to each maintenance dose as a loading dose twice, followed by each maintenance dose. Continuous, dashed, dash-dotted, and dotted lines show the simulations with the administration of 3, 4, 5, and 6 mg of warfarin, respectively. In panel B, INR transitions were simulated using parameter sets in which 1 of the parameters was changed based on interindividual variability (ω) from the population mean value. The warfarin maintenance dose and the vitamin K₂ dose were set to 3 mg and 20 mg, respectively. The continuous, dotted, dashed, and dash-dotted lines show the simulations using all population mean values, and changed parameters for k _s , IC _50, and k ₃₀ , respectively. The fine and bold lines show the simulations using + and - ω change from each population mean value, respectively