Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

Table 2 Final population pharmacokinetic and pharmacodynamic parameters

Mean parameters	Estimate	RSE
k _s (%/h)	3.97	17.5
k _d (1/h)	0.0611	9.90
IC ₅₀ (μg/mL)	0.604	24.5
E _max	0.324	15.9
EC ₅₀ (μg/mL)	5.30	17.6
k ₃₀ (1/h)	0.0194	19.2
θ	0.614	13.9
Interindividual variability	Estimate (CV%)	RSE
ω_ks ²	0.0704 (26.5)	25.6
ω_IC50 ²	0.144 (37.9)	43.3
ω_k30 ²	0.171 (41.4)	85.3
Residual variability (%)	Estimate (CV%)	RSE
σ²	0.0798 (28.2)	11.8

k _s, synthesis rate constant; k _d, degradation rate constant; IC ₅₀, 50 % inhibitory concentration of warfarin; E _max, maximum effect of vitamin K₂; EC ₅₀, 50 % effective concentration of vitamin K₂; k ₃₀, elimination rate constant of vitamin K₂; θ, a factor for the effect of decreased renal function on IC ₅₀; RSE, relative standard error

ISSN: 2055-0294