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Table 2 Final population pharmacokinetic and pharmacodynamic parameters

From: Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data

Mean parameters Estimate RSE
k s (%/h) 3.97 17.5
k d (1/h) 0.0611 9.90
IC 50 (μg/mL) 0.604 24.5
E max 0.324 15.9
EC 50 (μg/mL) 5.30 17.6
k 30 (1/h) 0.0194 19.2
θ 0.614 13.9
Interindividual variability Estimate (CV%) RSE
ω ks 2 0.0704 (26.5) 25.6
ω IC50 2 0.144 (37.9) 43.3
ω k30 2 0.171 (41.4) 85.3
Residual variability (%) Estimate (CV%) RSE
σ2 0.0798 (28.2) 11.8
  1. k s , synthesis rate constant; k d , degradation rate constant; IC 50 , 50 % inhibitory concentration of warfarin; E max , maximum effect of vitamin K2; EC 50 , 50 % effective concentration of vitamin K2; k 30 , elimination rate constant of vitamin K2; θ, a factor for the effect of decreased renal function on IC 50 ; RSE, relative standard error