|
Mean parameters
|
Estimate
|
RSE
|
|---|
|
k
s
(%/h)
|
3.97
|
17.5
|
|
k
d
(1/h)
|
0.0611
|
9.90
|
|
IC
50
(μg/mL)
|
0.604
|
24.5
|
|
E
max
|
0.324
|
15.9
|
|
EC
50
(μg/mL)
|
5.30
|
17.6
|
|
k
30
(1/h)
|
0.0194
|
19.2
|
|
θ
|
0.614
|
13.9
|
|
Interindividual variability
|
Estimate (CV%)
|
RSE
|
|
ω
ks
2
|
0.0704 (26.5)
|
25.6
|
|
ω
IC50
2
|
0.144 (37.9)
|
43.3
|
|
ω
k30
2
|
0.171 (41.4)
|
85.3
|
|
Residual variability (%)
|
Estimate (CV%)
|
RSE
|
|
σ2
|
0.0798 (28.2)
|
11.8
|
-
k
s
, synthesis rate constant; k
d
, degradation rate constant; IC
50
, 50 % inhibitory concentration of warfarin; E
max
, maximum effect of vitamin K2; EC
50
, 50 % effective concentration of vitamin K2; k
30
, elimination rate constant of vitamin K2; θ, a factor for the effect of decreased renal function on IC
50
; RSE, relative standard error
