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Table 1 Patient characteristics at baseline

From: Plasma tenofovir trough concentrations are associated with renal dysfunction in Japanese patients with HIV infection: a retrospective cohort study

 

Study patients

N = 11

Male sex, n (%)

11 (100)

Age (years) a

35 (32–45)

Body weight (kg) a

56.1 (51.6–67.3)

BMI (kg/m2) a

18.2 (17.6–22.8)

BSA (m2)

1.69 (1.60–1.79)

Serum creatinine (mg/dL) a

0.80 (0.70–0.80)

eGFR (mL/min · 1.73 m2) a

96.1 (81.9–103.1)

CKD stage, n (%)

 

1

7 (63.6)

2

4 (36.4)

3

0 (0)

4

0 (0)

5

0 (0)

CD4+ cell count (/μL) a

119 (37–211)

HIV RNA viral load (log10/mL) a

4.83 (4.61–5.85)

Protease inhibitors (ritonavir-boosted), n (%)

7 (63.6)

Protease inhibitors (unboosted), n (%)

0 (0)

NNRTIs, n (%)

0 (0)

INSTIs, n (%)

4 (36.4)

Concurrent use of a nephrotoxic drug, n (%)

4 (36.4)

Hypertension, n (%)

0 (0)

Diabetes, n (%)

0 (0)

Hepatitis B, n (%)

3 (27.3)

Hepatitis C, n (%)

0 (0)

Plasma TFV concentration (ng/mL) a

64.0 (56.0–90.5)

  1. BMI body mass index, BSA body surface area, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, NNRTIs non-nucleoside reverse-transcriptase inhibitors, INSTIs integrase strand transfer inhibitors, TFV tenofovir
  2. aValues are reported as median (interquartile range)