Parameter | Fixed effects model | OBJ | - 2 l.l.d. | p-value |
---|---|---|---|---|
CL | θ1 | 491.305 | ||
θ1 + θ2 × Ccr | 476.461 | −14.844 | 0.001 | |
θ1 + θ2 × 1 / Scr | 486.958 | −4.347 | N.S. | |
θ1 × θ2Gender (Gender: male = 1, female = 0) | 486.934 | −4.371 | N.S. | |
θ1; Age ≧ 65, θ2; Age < 65 | 491.291 | −0.014 | N.S. | |
θ1; Alb ≧ 3.8, θ2; Alb < 3.8 | 491.305 | 0 | N.S. | |
θ1 + θ2 × (1 + (4 - stage)) | 490.054 | −1.251 | N.S. | |
θ1 × θ2Procedure | 491.074 | −0.231 | N.S. | |
θ1 + θ2 × BW | 489.316 | −1.989 | N.S. | |
Vd | θ1 × θ2Gender (Gender : male = 1, female = 0) | 491.295 | 0.010 | N.S. |
θ1; Age ≧ 65, θ4; Age < 65 | 490.189 | 1.116 | N.S. | |
θ1 + θ2 × BW | 473.811 | 17.494 | 0.001 |