Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer

Table 2 Hypothesis testing for fixed efects model on cefmetazole parameters

Parameter	Fixed effects model	OBJ	- 2 l.l.d.	p-value
CL	θ1	491.305
	θ1 + θ2 × Ccr	476.461	−14.844	0.001
	θ1 + θ2 × 1 / Scr	486.958	−4.347	N.S.
	θ1 × θ2^Gender (Gender: male = 1, female = 0)	486.934	−4.371	N.S.
	θ1; Age ≧ 65, θ2; Age < 65	491.291	−0.014	N.S.
	θ1; Alb ≧ 3.8, θ2; Alb < 3.8	491.305	0	N.S.
	θ1 + θ2 × (1 + (4 - stage))	490.054	−1.251	N.S.
	θ1 × θ2^Procedure	491.074	−0.231	N.S.
	θ1 + θ2 × BW	489.316	−1.989	N.S.
Vd	θ1 × θ2^Gender (Gender : male = 1, female = 0)	491.295	0.010	N.S.
	θ1; Age ≧ 65, θ4; Age < 65	490.189	1.116	N.S.
	θ1 + θ2 × BW	473.811	17.494	0.001

ISSN: 2055-0294