Table 2 Hypothesis testing for fixed efects model on cefmetazole parameters

CL

θ1

491.305

θ1 + θ2 × Ccr

476.461

−14.844

0.001

θ1 + θ2 × 1 / Scr

486.958

−4.347

N.S.

θ1 × θ2^Gender (Gender: male = 1, female = 0)

486.934

−4.371

N.S.

θ1; Age ≧ 65, θ2; Age < 65

491.291

−0.014

N.S.

θ1; Alb ≧ 3.8, θ2; Alb < 3.8

491.305

0

N.S.

θ1 + θ2 × (1 + (4 - stage))

490.054

−1.251

N.S.

θ1 × θ2^Procedure

491.074

−0.231

N.S.

θ1 + θ2 × BW

489.316

−1.989

N.S.

Vd

θ1 × θ2^Gender (Gender : male = 1, female = 0)

491.295

0.010

N.S.

θ1; Age ≧ 65, θ4; Age < 65

490.189

1.116

N.S.

θ1 + θ2 × BW

473.811

17.494

0.001