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Table 4 Bootstrap validation of the estimated pharmacokinetic parameters

From: Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer

Parameter

Final modela (mean ± S.E.)

Bootstrapb (mean ± S.E.)

Differencec

θ1 (CL)

0.0704 ± 0.0029

0.0703 ± 0.0029

−0.001%

θ2 (Vd)

0.163 ± 0.0054

0.164 ± 0.0057

0.6%

ωCL

0.210 ± 0.0137

0.202 ± 0.0350

−3.8%

ωVd

0.084 ± 0.0053

0.070 ± 0.0377

−16.7%

σ

0.135 ± 0.0045

0.133 ± 0.0165

−1.5%

  1. aObtained from the original data set
  2. bCalculated from 200 bootstrap replications
  3. c{(Bootstrap value - Final model value)/Final model value} × 100