Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study

Table 5 Risk factors associated with Grade 3/4 neutropenia among 24 patients undergoing MVAC therapy at the first course, univariate logistic regression analysis

Variable	Incidence of severe neutropenia (%)	OR (95% CI)	P value
Dexamethasone	(+) : 94.4	17.0 (1.3–223.1)	0.03
Dexamethasone	(−) : 50.0
Age (>65 y)	(+) : 88.2	3.0 (0.33–27.2)	0.33
Age (>65 y)	(−) : 71.4
Female	Female : 75.0	0.5 (0.04–7.0)	0.63
Female	Man : 85.0
PS (>0)	(+) : 66.7	0.3 (0.02–4.9)	0.42
PS (>0)	(−) : 85.7
Total bilirubin (>0.5 mg/dL)	(+) : 90.9	3.0 (0.3–34.0)	0.38
Total bilirubin (>0.5 mg/dL)	(−) : 76.9
BMI (<23 kg/m2)	(+) : 84.6	1.2 (0.1–10.5)	0.86
BMI (<23 kg/m2)	(−) : 81.8

OR odds ratio, PS performance status, BMI body mass index, CI confidence interval

ISSN: 2055-0294