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Table 1 Characteristics of patients classified according to effectiveness of enoxaparin

From: Predictive factors for effectiveness and safety of enoxaparin for total knee arthroplasty in aged Japanese patients: a retrospective review

 

Effective

Ineffective

P value

Case, no. (%)

105 (82.0)

23 (18.0)

-

Age (years)a

77.2 ± 5.11

79.0 ± 4.51

0.10

Sex, no. (%)

 male

25 (23.8)

3 (13.0)

0.40

 female

80 (76.2)

20 (87.0)

 

Height (cm)b

150 (135–176)

145 (140–165)

0.08

Body weight (kg)b

57 (38–91)

51 (39–69)

0.11

Enoxaparin dose, no. (%)

 2000 mg/day

36 (34.3)

9 (39.1)

0.64

 4000 mg/day

69 (65.7)

14 (60.9)

 

Previous history of DVT, no. (%)

 yes

4 (3.81)

3 (13.0)

0.11

Use of tourniquet, no. (%)

 yes

35 (33.3)

15 (65.2)

<0.01

Operative time, (min)b

110 (65–260)

100 (75–210)

0.14

Volume of bleeding during surgery (mL)b

100 (0–1530)

70 (0–500)

0.33

Laboratory values at POD1

 Total serum protein (g/dL)a

5.85 ± 0.60

6.35 ± 0.53

<0.001

 Serum creatinine (mg/dL)b

0.68 (0.35–2.13)

0.64 (0.43–1.07)

0.15

 BUN (mg/dL)b

13.5 (7.4–24.3)

12.0 (8.6–20.0)

0.16

 AST (IU/L)b

20.0 (11.0–80.0)

20.0 (11.0–44.0)

0.68

 ALT (IU/L)b

13.0 (5.0–50.0)

12.0 (6.0–57.0)

0.50

 LDH (IU/L)b

199 (122–390)

216 (134–273)

0.20

 ALP (IU/L)b

185 (94–398)

181 (122–337)

0.78

 γ-GTP (IU/L)b

14 (7–460)

13 (8–143)

0.69

 ChE (IU/L)b

220 (108–401)

231 (144–316)

0.90

 Total bilirubin (mg/dL)b

0.8 (0.3–2.7)

0.9 (0.4–1.3)

0.74

 WBC (103/μL)b

90 (45–405)

82 (62–158)

0.57

 Hb (g/dL)a

10.9 ± 1.27

10.6 ± 1.21

0.28

 Platelet (104/μL)a

18.2 ± 5.93

17.7 ± 4.61

0.62

 CRP (mg/dL)b

4.57 (1.58–12)

5.52 (1.04–14.04)

0.41

Complications, no. (%)

 Hypertension

72 (68.6)

19 (82.6)

0.21

 Diabetes

13 (12.4)

2 (8.70)

1.00

 Dyslipidemia

30 (28.6)

6 (26.1)

1.00

 Chronic heart failure

6 (5.71)

0 (0.00)

0.59

 Cerebral vascular disease

6 (5.71)

0 (0.00)

0.59

Concomitant drugs, no. (%)

 NSAIDs

100 (95.2)

21 (91.3)

0.61

 Low dose aspirin

12 (11.4)

2 (8.70)

1.00

 Clopidogrel

2 (1.90)

1 (4.35)

0.45

 Ticlopidine

1 (0.95)

1 (4.35)

0.33

 Cilostazol

1 (0.95)

1 (4.35)

0.33

 Limaprost alfadex

5 (4.76)

3 (13.0)

0.15

 Warfarin

6 (5.71)

1 (4.35)

1.00

 Raloxifene

4 (3.81)

2 (8.70)

0.29

  1. aData are expressed as mean ± SD, bData are expressed as median (range)
  2. SE indicates standard error, POD1 post-operative day 1, BUN blood urea nitrogen, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, ALP alkaline phosphatase, γ-GTP γ-glutamyl transferase, ChE serum cholinesterase, WBC white blood cells, Hb hemoglobin, CRP C-reactive protein, NSAIDs non-steroid anti-inflammatory drugs