Table 1 Concentration of each drug in the additional experiment

Aspirin

17

Ibuprofen (maximum plasma concentration after taking ibuprofen 200 mg)

80.5 [19]

Ibuprofen (assumed concentration after 12 h of taking ibuprofen 200 mg)

2 [19]^a

Loxoprofen-trans-OH (maximum plasma concentration after taking loxoprofen 60 mg)

3.4 [20]

Loxoprofen-trans-OH (assumed concentration after 6 h of taking loxoprofen 60 mg)

0.16 [20]

Loxoprofen-trans-OH (assumed concentration after 12 h of taking loxoprofen 60 mg)

0.0046 [20]