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Table 1 MS/MS selected reaction monitoring transitions and collision energies for ions of metabolite and internal standard in the cocktail assays

From: Effect of health foods on cytochrome P450-mediated drug metabolism

  CYP1A2 CYP2C9 CYP2C19 CYP2D6 CYP3A4 IS
Substrate Phenacetin Diclofenac Omeprazole Dextromethorphan Midazolam Nitrazepam
Metabolite Acetaminophen 4′-Hydroxy-diclofenac 5-Hydroxy-omeprazole Dextrorphan 1′-Hydroxy-midazolam -
Collision energy (eV) 19 33 13 42 23 25
Product ion (m/z) 110.05 229.95 213.95 157.05 324.05 236.10