Skip to main content

Table 1 Demographic data in living donor renal transplant recipients

From: Usefulness of limited sampling strategy for mycophenolic acid area under the curve considering postoperative days in living-donor renal transplant recipients with concomitant prolonged-release tacrolimus

 

The number of patients (%) or median [minimum–maximum]

Male

17 (47.2)

Primary disease

 diabetic nephropathy

9 (25.0)

 IgA nephropathy

7 (19.4)

 polycystic kidney

3 (8.3)

 chronic glomerulonephritis

2 (5.5)

 focal glomerulosclerosis

2 (5.5)

 Alport syndrome

1 (2.7)

 cystinosis

1 (2.7)

 mesangial proliferative glomerulonephritis

1 (2.7)

 unknown

10 (26.0)

Agea

47 [28–66]

Body weight (kg)a

55.5 [34.8–105.9]

Serum albumin (g/dL)a

4.0 [2.9–5.1]

Serum creatinine (mg/dL)a

1.1 [0.5–2.9]

Estimated creatinine clearance (mL/min)a

57.5 [24.9–113.8]

Total bilirubin (mg/dL)a

0.6 [0.2–1.6]

Alanine aminotransferase (IU/mL)a

12 [4–117]

Aspartate aminotransferase (IU/mL)a

17 [6–109]

Mycophenolate mofetil dose at one time (mg)

 Postoperative day < 31

1000 [500–1000]

 Postoperative day ≥ 31

500 [250–1000]

Actual AUC0-12 of mycophenolic acid (μg▪h/mL)

 Postoperative day < 31

52.7 [23.6–89.2]

 Postoperative day ≥ 31

43.7 [21.5–87.6]

Oral clearance of mycophenolate acid

 Postoperative day < 31

18.0 [10.2–32.7]

 Postoperative day ≥ 31

12.5 [6.4–34.1]

Postoperative day

 Postoperative day < 31

14 [7–21]

 Postoperative day ≥ 31

359 [34–2832]

Concomitant druga ,b

 Postoperative day < 31

  Proton pump inhibitor

34 (34.0)

  Proton pump inhibitor + Quinolone

4 (4.0)

 Postoperative day ≥ 31

  Quinolone

22 (22.0)

  Proton pump inhibitor

16 (16.0)

  Proton pump inhibitor + Quinolone

17 (17.0)

  Proton pump inhibitor + Valganciclovir

2 (2.0)

  1. aThese data were measured on the day the AUC0-12 was determined (n = 100)
  2. bConcomitant drugs that may influence MPA pharmacokinetics were examined by using Lexicomp© integrated in UpToDate©(version 2014; Wolters Kluwer Health, Philadelphia, PA, USA)